The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia
- Creator: Rammos, Alexandros , Gonzalez, Lara A. Neira , Weinberger, Daniel R. , Mitchell, Kevin J. , Nicodemus, Kristin K. , Ripke, Stephan , Neale, Benjamin M. , Corvin, Aiden , Walters, James T. R. , Farh, Kai-How , Holmans, Peter A. , Lee, Phil , Bulik-Sullivan, Brendan , Collier, David , Huang, Hailiang , Pers, Tune H. , Agartz, Ingrid , Agerbo, Esben , Albus, Margot , Alexander, Madeline , Amin, Farooq , Bacanu, Silviu , Begemann, Martin , Belliveau, Richard , Bene, Judit , Cairns, Murray J. , Henskens, Frans A. , Kelly, Brian J. , Loughland, Carmel M. , Michie, Patricia T. , Schall, Ulrich , Scott, Rodney J. , Tooney, Paul A. , Wu, Jing Qin
- Resource Type: journal article
- Date: 2019
A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia
- Creator: Li, Wen , Fan, Chun Chieh , Mäki-Marttunen, Tuomo , Thompson, Wesley K. , Schork, Andrew J. , Bettella, Francesco , Ripke, Stephan , Neal, Benjamin M. , Corvin, Aiden , Walters, James T. R. , Farh, Kai-How , Holmans, Peter A. , Lee, Phil , Bulik-Sullivan, Brendan , Collier, David A. , Huang, Hailiang , Cairns, Murray J. , Henskens, Frans A. , Kelly, Brian J. , Michie, Patricia T. , Schall, Ulrich , Scott, Rodney J. , Tooney, Paul A. , Wu, Jing Qin , Djurovic, Srdjan , Dale, Andrew M. , Andreassen, Ole A. , Wang, Yunpeng
- Resource Type: journal article
- Date: 2018
Age at first birth in women is genetically associated with increased risk of schizophrenia
- Creator: Ni, Guiyan , Gratten, Jacob , Lee, Phil , Bulik-Sullivan, Brendan , Collier, David A. , Huang, Hailiang , Pers, Tune H. , Agartz, Ingrid , Agerbo, Esben , Albus, Margot , Alexander, Madeline , Amin, Farooq , Wray, Naomi R. , Henskens, Frans A. , Loughland, Carmel M. , Michie, Patricia T. , Schall, Ulrich , Scott, Rodney J. , Bevilacqua, E , Bigdeli, TB , Black, DW , Bruggeman, R , Buccola, NG , Lee, Sang Hong , Buckner, RL , Byerley, W , Cahn, W , Cai, G , Campion, D , Cantor, RM , Carr, VJ , Carrera, N , Catts, SV , Chambert, KD , Ripke, Stephan , Chan, RCK , Chen, RYL , Chen, EYH , Cheng, W , Cheung, EFC , Chong, SA , Cloninger, CR , Cohen, D , Cohen, N , Cormican, P , Neale, Benjamin M. , Craddock, N , Crowley, JJ , Curtis, D , Davidson, M , Davis, KL , Degenhardt, F , Del Favero, J , Demontis, D , Dikeos, D , Dinan, T , Corvin, Aiden , Djurovic, S , Donohoe, G , Drapeau, E , Walters, James T. R. , Farh, Kai-How , Holmans, Peter A.
- Resource Type: journal article
- Date: 2018
Analysis of shared heritability in common disorders of the brain
- Creator: Anttila, Verneri , Bulik-Sullivan, Brendan , Patsopoulos, Nikolaos A. , Ripke, Stephan , Wei, Zhi , Yu, Dongmei , Lee, Phil H. , Turley, Patrick , Grenier-Boley, Benjamin , Chouraki, Vincent , Kamatani, Yoichiro , Berr, Claudine , Finucane, Hilary K. , Holliday, Elizabeth , Attia, John , Cairns, Murray , Loughland, Carmel , Schall, Ulrich , Henskens, Frans , Scott, Rodney , Reitz, C , Goate, AM , Huentelman, MJ , Walters, Raymond K. , Ilyas Kamboh, M , Larson, EB , Rogaeva, E , George-Hyslop, PS , Hakonarson, H , Kukull, WA , Farrer, LA , Barnes, LL , Beach, TG , Yesim Demirci, F , Bras, Jose , Head, E , Hulette, CM , Jicha, GA , Kauwe, JSK , Kaye, JA , Leverenz, JB , Levey, AI , Lieberman, AP , Pankratz, VS , Poon, WW , Duncan, Laramie , Quinn, JF , Saykin, AJ , Schneider, LS , Smith, AG , Escott-Price, Valentina , Falcone, Guido J. , Gormley, Padhraig , Malik, Rainer
- Resource Type: journal article
- Date: 2018
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood
- Creator: Ni, Guiyan , Moser, Gerhard , Ripke, Stephan , Neale, Benjamin M. , Corvin, Aiden , Walters, James T. R. , Farh, Kai-How , Holmans, Peter A. , Lee, Phil , Bulik-Sullivan, Brendan , Collier, David A. , Huang, Hailiang , Pers, Tune H. , Agartz, Ingrid , Agerbo, Esben , Albus, Margot , Alexander, Madeline , Amin, Farooq , Bacanu, Silviu A. , Henskens, Frans A. , Loughland, Carmel A. , Michie, Patricia T. , Schall, Ulrich , Scott, Rodney J. , Wray, Naomi R. , Lee, S. Hong
- Resource Type: journal article
- Date: 2018
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
- Creator: Ruderfer, Douglas M. , Ripke, Stephan , McQuillin, Andrew , Boocock, James , Stahl, Eli A. , Pavlides, Jennifer M. Whitehead , Mullins, Niamh , Charney, Alexander W. , Ori, Anil P. S. , Loohuis, Loes M. Olde , Domenici, Enrico , Di Florio, Arianna , Papiol, Sergi , Kalman, Janos L. , Trubetskoy, Vassily , Adolfsson, Rolf , Agartz, Ingrid , Agerbo, Esben , Akil, Huda , Albani, Diego , Albus, Margot , Cairns, Murray J. , Henskens, Frans A. , Kelly, Brian J. , Loughland, Carmel M. , Michie, Patricia T. , Schall, Ulrich , Scott, Rodney J. , Tooney, Paul A. , Wu, Jing Qin
- Resource Type: journal article
- Date: 2018
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
- Creator: Marshall, Christian R. , Howrigan, Daniel P. , Gujral, Madhusudan , Brandler, William M. , Malhotra, Dheeraj , Wang, Zhouzhi , Fuentes Fajarado, Karin V. , Maile, Michelle S. , Ripke, Stephan , Agartz, Ingrud , Albus, Margot , Alexander, Madeline , Merico, Daniele , Atkins, Joshua , Cairns, Murray J. , Carr, Vaughan J. , Henskens, Frans A. , Kelly, Brian J. , Loughland, Carmel L. , Michie, Patricia T. , Schall, Ulrich , Scott, Rodney J. , Tooney, Paul A. , Thiruvahindrapuram, Bhooma , Wu, Jing Qin , Wu, Wenting , Greer, Douglas S. , Antaki, Douglas , Shetty, Aniket , Holmans, Peter A. , Pinto, Dalila
- Resource Type: journal article
- Date: 2017
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
- Creator: Franke, Barbara , Stein, Jason L. , Ripke, Stephan , Anttila, Verneri , Hibar, Derrek P. , van Hulzen, Kimm J. E.JE , Arias-Vasquez, Alejandro , Smoller, Jordan W. , Nichols, Thomas E. , Neale, Michael C. , McIntosh, Andrew M. , Lee, Phil , McMahon, Francis J. , Meyer-Lindenberg, Andreas , Mattheisen, Manuel , Andreassen, Ole A. , Gruber, Oliver , Sachdev, Perminder S. , Roiz-Santiañez, Roberto , Saykin, Andrew J. , Schizophrenia Working Group of the Psychiatric Genomics Consortium , Enigma Consortium , Cairns, Murray J. , Henskens, Frans A. , Kelly, Brian J. , Loughland, Carmel M. , Michie, Patricia T. , Schall, Ulli , Scott, Rodney J. , Tooney, Paul A. , Wu, Jing Qin , Hansen, Mitchell , Lee, Steve , Liu, Xiaochun
- Resource Type: journal article
- Date: 2016
Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness
- Creator: Bigdeli, Tim B. , Ripke, Stephan , Kirov, George , McQuillin, Andrew , Gurling, Hugh , Rujescu, Dan , Andreassen, Ole A. , Werge, Thomas , Blackwood, Douglas H. R. , Pato, Carlos N. , Pato, Michele T. , Malhotra, Anil K. , Bacanu, Silviu-Alin , O'Donovan, Michael C. , Kendler, Kenneth S. , Fanous, Ayman H. , Schizophrenia Working Group of the Psychiatric Genomics Consortium, , Henskens, Frans A. , Lee, Sang Hong , Wray, Naomi R. , Gejman, Pablo V. , Rietschel, Marcella , Cichon, Sven , St Clair, David , Corvin, Aiden
- Resource Type: journal article
- Date: 2016
Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts
- Creator: Ek, Weronica E. , Reznichenko, Anna , Holliday, Elizabeth G. , Houghton, Lesley , Gazouli, Maria , Karamanolis, George , Rappold, Gudrun , Burwinkel, Barbara , Surowy, Harald , Rafter, Joseph , Assadi, Ghazaleh , Li, Ling , Ripke, Stephan , Niesler, Beate , Zucchelli, Marco , Rivera, Natalia V. , Schmidt, Peter T. , Pedersen, Nancy L. , Magnusson, Patrik , Talley, Nicholas J.
- Resource Type: journal article
- Date: 2015
LD score regression distinguishes confounding from polygenicity in genome-wide association studies
- Creator: Bulik-Sullivan, Brendan K. , Albus, M , Alexander, M , Amin, F , Bacanu, SA , Begemann, M , Belliveau, RA , Bene, J , Bergen, SE , Bruggeman, R , Bevilacqua, E , Bigdeli, TB , Black, DW , Buccola, NG , Buckner, RL , Byerley, W , Cahn, W , Cai, G , Cairns, MJ , Campion, D , Cantor, RM , Carr, VJ , Carrera, N , Catts, SV , Chambert, KD , Chan, RCK , Chen, RYL , Cohen, D , Chen, EYH , Cheng, W , Cheung, EFC , Chong, SA , Cloninger, CR , Cohen, N , Cormican, P , Craddock, N , Crespo-Facorro, B , Crowley, JJ , Curtis, D , Davidson, M , Davis, KL , Degenhardt, F , Del Favero, J , Loh, Po-Ru , Michie, Patricia T. , Schall, Ulrich , Scott, Rodney J. , Tooney, Paul A. , Wu, Jing Qin , Patterson, Nick , Daly, Mark J. , Price, Alkes L. , Neale, Benjamin M. , Finucane, Hilary K. , Ripke, Stephan , Yang, Jian , Schizophrenia Working Group of the Psychiatric Genomics Consortium, , Cairns, Murray J. , Henskens, Frans A. , Kelly, Brian J. , Loughland, Carmel M.
- Resource Type: journal article
- Date: 2015
Modeling linkage disequilibrium increases accuracy of polygenic risk scores
- Creator: Vilhjálmsson, Bjarni J. , Yang, Jian , Hayeck, Tristan , Won, Hong-Hee , Schizophrenia Working Group of the Psychiatric Genomics Consortium, , Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study, , Finucane, Hilary K. , Gusev, Alexander , Lindström, Sara , Ripke, Stephan , Genovese, Giulio , Loh, Po-Ru , Bhatia, Gaurav , Do, Ron
- Resource Type: journal article
- Date: 2015
Partitioning heritability by functional annotation using genome-wide association summary statistics
- Creator: Finucane, Hilary K. , Bulik-Sullivan, Brendan , Ripke, Stephan , Day, Felix R. , ReproGen Consortium, , Schizophrenia Working Group of the Psychiatric Genomics Consortium, , The RACI Consortium, , Purcell, Shaun , Stahl, Eli , Lindstrom, Sara , Perry, John R. B. , Okada, Yukinori , Gusev, Alexander , Raychaudhuri, Soumya , Daly, Mark J. , Patterson, Nick , Neale, Benjamin M. , Price, Alkes L. , Henskens, Frans A. , Loughland, Carmel M. , Michie, Patricia T. , Schall, Ulrich , Scott, Rodney J. , Trynka, Gosia , Tooney, Paul A. , Wu, Jing Qin , Reshef, Yakir , Loh, Po-Ru , Anttila, Verneri , Xu, Han , Zang, Chongzhi , Farh, Kyle
- Resource Type: journal article
- Date: 2015
Biological insights from 108 schizophrenia-associated genetic loci
- Creator: Ripke, Stephan , Neale, Benjamin M. , Pers, Tune H. , Julià, Antonio , Kahn, René S. , Kalaydjieva, Luba , Karachanak-Yankova, Sena , Karjalainen, Juha , Kavanagh, David , Keller, Matthew C. , Kennedy, James L. , Khrunin, Audrey , Kim, Yunjung , Agartz, Iingrid , Klovins, Janis , Knowles, James A. , Konte, Bettina , Kucinskas, Vaidutis , Ausrele Kucinskiene, Zita , Kuzelova-Ptackova, Hana , Kähler, Anna K. , Laurent, Claudine , Lee Chee Keong, Jimmy , Hong Lee, S. , Agerbo, Esben , Legge, Sophie E. , Lerer, Bernard , Li, Miaoxin , Li, Tao , Liang, Kung-Yee , Lieberman, Jeffrey , Limborska, Svetlana , Loughland, Carmel M. , Lubinski, Jan , Lönnqvist, Jouko , Albus, Margot , Macek Jr, Milan , Magnusson, Patrik K. E. , Maher, Brion S. , Maier, Wolfgang , Mallet, Jacques , Marsal, Sara , Mattheisen, Manuel , Mattingsdal, Morten , McCarley, Robert W. , McDonald, Colm , Alexander, Madeline , McIntosh, Andrew M. , Meier, Sandra , Meijer, Carin J. , Melegh, Bela , Melle, Iingrid , Mesholam-Gately, Raquelle I. , Metspalu, Andres , Michie, Patricia T. , Milani, Lili , Milanova, Virha , Amin, Farooq , Mokrab, Younes , Morris, Derek W. , Mors, Ole , Murphy, Kieran C. , Murray, Robin M. , Myin-Germeys, Inez , Müller-Myhsok, Bertram , Nelis, Mari , Nenadic, Igor , Nertney, Deborah A. , Bacanu, Silviu A. , Nestadt, Gerald , Nicodemus, Kristin K. , Nikitina-Zake, Liene , Nisenbaum, Laura , Nordin, Annelie , O'Callaghan, Eadbhard , O'Dushlaine, Colm , O'Neill, F. Anthony , Oh, Sang-Yun , Olincy, Ann , Begemann, Martin , Olsen, Line , Van Os, Jim , Psychosis Endophenotypes International Consortium , Pantelis, Christos , Papadimitriou, George N. , Papiol, Sergi , Parkhomenko, Elena , Pato, Michele T. , Paunio, Tiina , Pejovic-Milovancevic, Milica , Belliveau Jr, Richard A. , Perkins, Diana O. , Pietiläinen, Olli , Pimm, Jonathan , Pocklington, Andrew J. , Powell, John , Price, Alkes , Pulver, Ann E. , Purcell, Shaun M. , Quested, Digby , Rasmussen, Henrik B. , Bene, Judit , Reichenberg, Abraham , Reimers, Mark A. , Richards, Alexander L. , Roffman, Joshua L. , Roussos, Panos , Ruderfer, Douglas M. , Salomaa, Veikko , Sanders, Alan R. , Schall, Ulrich , Schubert, Christian R. , Corvin, Aiden , Bergen, Sarah E. , Schulze, Thomas G. , Schwab, Sibylle G. , Scolnick, Edward M. , Scott, Rodney J. , Seidman, Larry J. , Shi, Jianxin , Sigurdsson, Engilbert , Silagadze, Teimuraz , Silverman, Jeremy M. , Sim, Kang , Bevilacqua, Elizabeth , Slominsky, Petr , Smoller, Jordan W. , So, Hon-Cheong , Spencer, Chris C. A. , Stahl, Eli A. , Stefansson, Hreinn , Steinberg, Stacy , Stogmann, Elisabeth , Straub, Richard E. , Strengman, Eric , Bigdeli, Tim B. , Strohmaier, Jana , Scott Stroup, T. , Subramaniam, Mythily , Suvisaari, Jaana , Svrakic, Dragan M. , Szatkiewicz, Jin P. , Söderman, Erik , Thirumalai, Srinivas , Toncheva, Draga , Tosato, Sarah , Black, Donald W. , Veijola, Juha , Waddington, John , Walsh, Dermot , Wang, Dai , Wang, Qiang , Webb, Bradley T. , Weiser, Mark , Wildenauer, Dieter B. , Williams, Nigel M. , Williams, Stephanie , Bruggeman, Richard , Witt, Stephanie H. , Wolen, Aaron R. , Wong, Emily H. M. , Wormley, Brandon K. , Simon Xi, Hualin , Zai, Clement C. , Zheng, Xuebin , Zimprich, Fritz , Wray, Naomi R. , Stefansson, Kari , Buccola, Nancy G. , Visscher, Peter M. , Welcome Trust Case-Control Consortium, , Adolfsson, Rolf , Andreassen, Ole A. , Blackwood, Douglas H. R. , Bramon, Elvira , Buxbaum, Joseph D. , Børglum, Anders D. , Cichon, Sven , Darvasi, Ariel , Buckner, Randy L. , Domenici, Enrico , Ehrenreich, Hannelore , Esko, Tõnu , Gejman, Pablo V. , Gill, Michael , Gurling, Hugh , Hultman, Christina M. , Iwata, Nakao , Jablensky, Assen V. , Jönsson, Erik G. , Byerley, William , Kendler, Kenneth S. , Kirov, George , Knight, Jo , Lencz, Todd , Levinson, Douglas F. , Li, Qingqin S. , Liu, Jianjun , Malhotra, Anil K. , McCarroll, Steven A. , McQuillin, Andrew , Cahn, Wiepke , Moran, Jennifer L. , Mortensen, Preben B. , Mowry, Bryan J. , Nöthen, Markus M. , Ophoff, Roel A. , Owen, Michael J. , Palotie, Aarno , Pato, Carlos N. , Petryshen, Tracey L. , Posthuma, Danielle , Cai, Guiqing , Rietschel, Marcella , Riley, Brien P. , Rujescu, Dan , Sham, Pak C. , Sklar, Pamela , St Clair, David , Weinberger, David R. , Wendland, Jens R. , Werge, Thomas , Daly, Mark J. , Walters, James T. R. , Campion, Dominique , Sullivan, Patrick F. , O'Donovan, Michael C. , Cantor, Rita M. , Carr, Vaughan J. , Carrera, Noa , Catts, Stanley V. , Chambert, Kimberly D. , Chan, Raymond C. K. , Chen, Ronald Y. L. , Chen, Eric Y. H. , Cheng, Wei , Farh, Kai-How , Cheung, Eric F. C. , Ann Chong, Siow , Robert Cloninger, C. , Cohen, David , Cohen, Nadine , Cormican, Paul , Craddock, Nick , Crowley, James J. , Curtis, David , Davidson, Michael , Holmans, Peter A. , Davis, Kenneth L. , Degenhardt, Franziska , Del Favero, Jurgen , Demontis, Ditte , Dikeos, Dimitris , Dinan, Timothy , Djurovic, Srdjan , Donohoe, Gary , Drapeau, Elodie , Duan, Jubao , Lee, Phil , Dudbridge, Frank , Durmishi, Naser , Eichhammer, Peter , Eriksson, Johan , Escott-Price, Valentina , Essioux, Laurent , Fanous, Ayman H. , Farrell, Martilias S. , Frank, Josef , Franke, Lude , Bulik-Sullivan, Brendan , Freedman, Robert , Freimer, Nelson B. , Friedl, Marion , Friedman, Joseph I. , Fromer, Menachem , Genovese, Giulio , Georgieva, Lyudmila , Giegling, Ina , Giusti-Rodríguez, Paola , Godard, Stephanie , Collier, David A. , Goldstein, Jacqueline I. , Golimbet, Vera , Gopal, Srihari , Gratten, Jacob , de Haan, Lieuwe , Hammer, Christian , Hamshere, Marian L. , Hansen, Mark , Hansen, Thomas , Haroutunian, Vahram , Huang, Hailiang , Hartmann, Annette M. , Henskens, Frans A. , Herms, Stefan , Hirschhorn, Joel N. , Hoffmann, Per , Hofman, Andrea , Hollegaard, Mads V. , Hougaard, David M. , Ikeda, Masashi , Joa, Inge
- Resource Type: journal article
- Date: 2014
No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis
- Creator: Goris, An , van Setten, Jessica , Diekstra, Frank , Ripke, Stephan , Patsopoulos, Nikolaos A. , Sawcer, Stephen J. , The International Multiple Sclerosis Genetics Consortium , van Es, Michael , The Australia and New Zealand MS Genetics Consortium , Andersen, Peter M. , Melki, Judith , Meininger, Vincent , Hardiman, Orla , Landers, John E. , Brown, Robert H. , Shatunov, Aleksey , Leigh, Nigel , Al-Chalabi, Ammar , Shaw, Christopher E. , Traynor, Bryan J. , Chio, Adriano , Restagno, Gabriella , Mora, Gabriele , Ophoff, Roel A. , Oksenberg, Jorge R. , Van Damme, Philip , Compston, Alastair , Robberecht, Wim , Dubois, Bénédicte , van den Berg, Leonard H. , De Jager, Philip L. , Veldink, Jan H. , de Bakker, Paul I. W.
- Resource Type: journal article
- Date: 2014
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
- Creator: Gusev, Alexander , Lee, S. Hong , Kähler, Anna K. , Hultman, Christina M. , Purcell, Shaun M. , McCarroll, Steven A. , Daly, Mark , Pasaniuc, Bogdan , Sullivan, Patrick F. , Neale, Benjamin M. , Wray, Naomi R. , Raychaudhuri, Soumya , Trynka, Gosia , Price, Alkes L. , Finucane, Hilary , Vilhjálmsson, Bjarni J. , Xu, Han , Zang, Chongzhi , Ripke, Stephan , Bulik-Sullivan, Brendan , Stahl, Eli
- Resource Type: journal article
- Date: 2014
Genetic schizophrenia risk variants jointly modulate total brain and white matter volume
- Creator: Terwisscha van Scheltinga, Afke F. , Schall, U , Michie, P , Carr, VJ , Scott, RJ , Bakker, Steven C. , Kahn, René S. , van Haren, Neeltje E. M. , Derks, Eske M. , Buizer-Voskamp, Jacobine E. , Boos, Heleen B. M. , Cahn, Wiepke , Hulshoff Pol, Hilleke E. , Ripke, Stephan , Ophoff, Roel A.
- Resource Type: journal article
- Date: 2013